Confrontation with Megatron in Sector 49G required thicker armor and massive firepower to combat the Decepticon leader's own upgraded flight mode, rapid launch Destronium Missiles, and lightning speed when combined with Lieutenant Starscream. On Mirtonia at the outer reaches of the Decepticon Star Empire, what became the final battle between Autobots and Decepticons raged savagely. The Decepticons laid waste to city and structure, but General Optimus Prime and his Firestormer squadron of Sgt. Hound, Air Raid, Strafe, Jetfire, and Autobot Jazz stood fast and valiant. The fighting edged towards yet another stand still until an errant missile slammed into a refinery processing an experimental form of energon. The resulting explosion vaporized Megatron, Starscream, and Communications Officer Soundwave while ripping a hole in reality that General Optimus Prime and Sgt. Hound tumbled through.

Rebooting in Axiom Nexus, General Optimus Prime soon found himself recruited into The Convoy - a group of heroic leaders meant to safeguard the entirety of the multiverse. While the others of the Convoy stayed in the upper city of Axiom Nexus, the General used his unusual appearance for a Prime for missions into the Low-Tech under city. This access to that populace also made him a valuable tool for Transtech Security Administration Officer Cheetor.